Obesity

Role of Steroids and Hormones in Obesity

It has been shown that hormones, including sex hormones and glucocorticoids, influence a variety of cellular processes in the central nervous system, including neurodevelopment and neurodegeneration. Glucocorticoid activity and the hypothalamic-pituitary-adrenal axis are involved in neurodegenerative processes, including those that lead to diseases like Alzheimer's and Parkinson's. It has demonstrated that sex hormones can alter cognitive performance. Given that the pathogenesis of neurodegeneration may be greatly influenced by gonadal and/or adrenal steroids. Neuroinflammation and Steroidal Hormones: After a physiological or psychologically induced stressful stimuli, the adrenal glands release glucocorticoids that promote anti-inflammatory and immunosuppressive effects via a variety of genomic and non-genomic processes, including the up regulation of anti-inflammatory gene expression. Sex hormones: Levels of C-reactive protein, -glut amyl transferase, and white blood cell and granulocyte count were some of the markers of metabolic syndrome and inflammation that were negatively linked with testosterone and sex hormone-binding globulin (SHBG) levels.