Lucy Baldeon
Central University of Ecuador, Ecuador
Title: Obesity in Caucasian T2D patients associates with higher levels of Leptin and Inflammatory Cytokines: This is not the case in Mestizo T2D patients
Biography
Biography: Lucy Baldeon
Abstract
Introduction: Recently we published on a set of T2D-related cytokines, chemokines and growth factors (TNFα, IL-1β, IL-6, HGF, PAI, Resistin, CCL2, Adiponectin, Leptin, IL-8, and CCL4) measured in the serum of mestizo (Ecuadorian) T2D ambulatory patients and their respective non-diabetic controls. We only found IL-8 and HGF significantly raised in T2D patients versus the non-diabetic controls. We concluded that the mestizo T2D patients only showed mild signs of a raised inflammatory state in serum.
Aim: To test a set of T2D-related cytokines, chemokines and growth factors in the serum of comparable Caucasian (Dutch) and Mestizo (Ecuadorian) T2D patients with the same array system.
Methods: Using a commercially available multi analyte cytometric bead array system, the serum of age and gender comparable Ecuadorian and Dutch T2D cases and their respective non-diabetic controls were tested. Statistical analysis was performed using SPSS. Data was tested for normal distribution using the Kolmogorov-Smirnov test. Depending on the distribution pattern and the total number of subjects, nonparametric group comparison (Mann-Whitney U test) was applied. Correlations were determined by Spearman correlation. Level of significance were set at p= 0.05 (two tailed).