Elisabeth Eppler
University of Basel, Switzerland
Title: Model systems in obesity and diabetes mellitus research: What can we learn from different species and methodological approaches?
Biography
Biography: Elisabeth Eppler
Abstract
Diabetes mellitus together with cardiovascular disease is a leading cause of death worldwide. Aside known risk factors for diabetes mellitus such as obesity and genetic predisposition, chronic inflammation has been detected to be an indispensable feature in the pathogenesis of diabetes mellitus. Different types of diabetes mellitus exist and different model systems in diverse species are applied in research and treatment. We discuss the use of different species and morphofunctional approaches applied in current research for optimized treatment options such as pharmacological and immunomodulatory treatment as well as islet transplantation and generation of beta cells derived from pluripotent stem cells.