Yi-Hao Yu
Greenwich Hospital, USA
Title: Towards individualized therapy for obesity: A heterogeneous disorder
Biography
Biography: Yi-Hao Yu
Abstract
Obesity is a heterogeneous disorder of various causes. To make treatment most eff ective, therapy must be tailored to individuals who manifest obesity with diff erent underlying etiologies. Monogenic forms of obesity are rare, but some of them where correction of the underlying defect is attainable provide opportunities for showcasing individualized treatment principles and favorable outcomes. The common forms of obesity are polygenic in nature. While the exact genetic defects in the affected individuals are not known, most of them manifest as predominantly metabolic obesity or hedonic obesity, which should be treated diff erentially with tailored interventions whenever possible. More importantly at this time, we advocate that existing therapies and treatment modalities under development be evaluated for their optimal therapeutic effi cacy separately in patients with metabolic obesity and those with hedonic obesity.