Biography
Biography: Edita Stokic
Abstract
During past few years the prevalence of obesity has increased dramatically Obesity traditionally has been defined as arndisease characterized by body fat accumulation to an extent that causes health disturbances, such as insulin resistance,type 2 diabetes mellitus, hypertension, dyslipidemia, cardiovascular disease, stroke, sleep apnea, gallbladder disease and somerntypes of cancer. On the other side, obesity isn’t a homogeneous disease - cardiometabolic disturbances which are associatedrnwith obesity, do not, however, affect all obese people.Several studies suggest that “Metabolically healthy but obese” - MHO people show specific phenotype and body composition differences compared with obese patients “at risk”. MHO individuals exhibit lower total and intraabdominal fat mass, lower ectopic fat accumulation and favorable metabolic, hormonal, immune and inflammatory profile. It is not clear what inducesrnpotential transition from metabolically healthy to unhealthy profile, and whether genetic, environmental, lifestyle and psychosocial factors have role. Metabolically obese but normal weight – MONW individuals present a subgroup of individualsrnwith normal BMI, and with insulin resistance, higher risk of developing type 2 diabetes, cardiovascular disease, atherosclerosis and mortality.The early identification of individuals with the MONW phenotype would be beneficial and may have important therapeutic implications. Clinical guidelines should be target more to MHO population, especially to standardization of definition criteria.Future studies should elucidate mechanisms of preserved favorable metabolic profile, and specific dynamics of metabolic and neuroendocrine processes in MHO individuals, which may be helpful in tailoring potential interventions.