Isaac Ampong
School of Medical Sciences University of Cape, Coast Ghana
Title: Effect of vegetable oil consumption on the management of Type 2 Diabetes Mellitus in diabetic mice model
Biography
Biography: Isaac Ampong
Abstract
Free fatty acids have been reported to impair insulin action, and also sufficient evidence implicates dietary fat composition in the development of insulin resistance, including impaired fasting glycemia and Type 2 diabetes mellitus. The work was designed to determine the effect of vegetable oils consumption on diabetes control in diabetic mice. Forty eight (48) diabetic mice were randomly divided into eight groups of six animals each. The first four groups were fed on chow (control), 10% Red palm oil feed, 10% groundnut oil feed, and 10% coconut oil respectively. The second four groups were fed similar to the first four groups but in addition were administered with glibenclamide (2mg/kg b-wt) daily for the four weeks. Total cholesterol was significantly reduced (p < 0.05) in mice fed on groundnut oil only and also in those on the control and palm oil diets plus glibenclamide treatment. There was also significant reduction (p < 0.05) in plasma LDL levels in mice fed on groundnut oil diet only and those on the control, palm oil, groundnut oil and coconut oil plus glibenclamide. HDL cholesterol was significantly increased in mice on groundnut oil only, and in mice fed on groundnut oil and coconut oil plus glibenclamide. However, triglycerides were significantly increased (p < 0.05) in the plasma of the mice on groundnut oil plus glibenclamide treatment. Plasma glucose was significantly reduced in all treatment (p < 0.05). Ten percent fortified vegetable oil feeds (palm oil, groundnut oil and coconut oil) significantly improved lipid profile and significantly reduced blood glucose in diabetic mice.